Asthma is an increasingly common disorder, particularly in industrialised countries where incidence and mortality are on the increase. Allergic asthma is a complex disease characterised by a hyperresponsiveness of the airways along with an accumulation of inflammatory cell infiltrate, in particular, Th2 cells characterised by production of proinflammatory cytokines IL-5, IL-4 and IL-13.
Rheumatoid arthritis is a chronic condition causing pain swelling and stiffness in the joints caused by synovial inflammation leading to bone and cartilage damage. Inflammation is driven by infiltration of immune cells such as T cells, macrophages, B cells and granulocytes, which can all be targeted therapeutically.
Aquila offers specific Immunology screening programs which can be tailored to address specific mechanisms of action and therapeutic questions relevant to the spectrum of autoimmune diseases. This is often designed as a phenotypic screen in which specific cell types (T cells polarised to a particular phenotype or other cell types implicated in the disease in question) are interrogated in the presence of compound with the resultant data able to point to clinical indication.
Beyond the in vitro level, there are a number of experimental models for autoimmune diseases such as asthma, arthritis and more. The academic expertise available to Aquila BioMedical allows us to develop novel, biologically-relevant models of disease, as well as potentially offering standard models for routine screening.
Please contact us for further information on our service offerings and possibilities in this area.